Antibiotics Delete Gut Diversity

It can take six months to regain a normal microbiome after using antibiotics, and chances are good that not all of the microbes present before the antibiotics were administered will return. Researchers in Copenhagen conducted a small study (12 men) that examined gut diversity after a single course of antibiotics. They used 3 drugs considered antibiotics of last resort: meropenem, gentamicin, and vancomycin. While the gut microbes of the subjects recovered, 9 common species of gut bacteria could no longer be detected in their microbiome. Oluf Pedersen is the lead scientist of the study.

In this case, it is good that we can regenerate our gut microbiota which is important for our general health…The concern, however, relates to the potentially permanent loss of beneficial bacteria after multiple exposures to antibiotics during our lifetime.”

Related: How To Heal Your Gut

Only One

This is what happens after a single course of antibiotics. What happens in the U.S., where outpatient healthcare providers prescribed more than 266 million courses of antibiotics in 2014, a third of which the CDC says are unnecessary? The same year saw an average of 835 antibiotic prescriptions for every 1,000 people. People who suffer from recurrent urinary tract infections (UTI) or chronic respiratory infections are likely given multiple courses of antibiotics in a single year. If it takes six months to mostly recover from a single course of antibiotics, those who take multiple courses are losing their chance to have a healthy, balanced microbiome.

It’s common to see articles comparing the gut bacteria of indigenous tribes with that of your average American. The indigenous microbiome is always more diverse. M. Gloria Dominguez-Bello is a microbiologist at the New York University School of Medicine and one of the authors of a study of the Yanomami tribe, first visited by the modern world in 2009. While Dominguez-Bello mentions diet, she also notes the difference in antibiotic use. The 2009 visit to the Yanomami in the Amazon is the first time the tribe was exposed to antibiotics, which can have a serious effect on gut health. Domingues-Bello says,

Antibiotics kill bacteria in the gut, and sometimes species don’t come back…This is especially true with children, whose microbiomes are in the process of getting assembled. Impacts on the microbiome at a young age can have long-lasting consequences.”

Recommended: Best Supplements To Kill Candida and Everything Else You Ever Wanted To Know About Fungal Infections

More and Different and Better

Is it possible to replenish your gut bacteria after a course of antibiotics? The answer is both yes and no. You can bring your microbes back, but they will no longer be the same. Each time the microbiome is mowed down and resurrected, diversity and the immune system’s ability to adapt are reduced. Combine that news with the rise of antibiotic-resistant bacteria and you should want to be as far away from antibiotics as well. It pays to take a look at the other likely reason for indigenous peoples microbiome diversity: diet.

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FDA Loophole That Allows Farmers To Administer Antibiotics Indefinitely

Antibiotics benefit farmers by speeding up the time it takes livestock to be ready for slaughter. Cows and chickens and other livestock grow faster with antibiotic use than they would otherwise. For cattle, the time from birth to slaughter can be cut in half. But antibiotic resistance is a growing public health concern.  Antibiotic-resistant bacteria like e.coli can be pathogenic to humans and even deadly. Farm water runoff and animal waste are damaging our ecosystems in a myriad of ways. Consequently, in 2017 the FDA was compelled to act.

The C.D.C. states that 23,000 Americans die each year due to antibiotic-resistant bacterial infections and they estimate that more than 400,000 United States residents become ill with infections caused by antibiotic-resistant food-borne bacteria every year. They believe that one in five of these antibiotic-resistant infections may be caused by pathogens from food and animals.

Recommended: Best Supplements To Kill Candida and Everything Else You Ever Wanted To Know About Fungal Infections

In 2017, the Food and Drug Administration enacted rules that prohibited antibiotics from being used for growth promotion in livestock. Previously these antibiotics could be purchased over the counter but the new rules require a prescription from a veterinarian.

Despite the ban, it’s widely believed that ranchers still use antibiotics to speed growth. The F.D.A. rules have a glaring loophole: farmers can use antibiotics for disease prevention.

You don’t even need a sick animal in the herd to use antibiotics in the feed and water as long as the justification is ‘disease prevention’ not ‘growth promotion,’ ” Avinash Kar, a senior attorney at the Natural Resources Defense Council

Courtesy of the CDDEP

More in-depth reading: Antibiotics in Meat Could Be Damaging Our Guts & New Report Tracks Rise of Antibiotic Resistance in Humans and Livestock

Our health depends on our gut’s ecosystem. Antibiotics, vaccinations, glyphosate, and GMOs are known to disrupt the bacteria in our gut. If you eat meat, we recommend careful consideration regarding who your buy meat from.

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Popular Antibiotics May Increase Susceptibility to Serious Heart Condition

Researchers at Baylor University in Texas looked at the effect of fluoroquinolones, a commonly prescribed family of antibiotics that includes Ciproflaxin, on aortic aneurysms and dissections in mice. One group of mice was fed a high-fat diet while the control group was given a standard diet. Mice on a high-fat diet who were then given antibiotics experienced an increased likelihood of an aortic dissection developing. They also produced less of the enzymes needed to stabilize collagen and experienced nuclear and mitochondrial DNA damage. According to the study,

Although ciprofloxacin alone does not induce spontaneous AAD (aortic aneurysms and dissections), it significantly increases susceptibility to challenge-induced aortic dissection and rupture in a mouse model of sporadic AAD. As a potent DNA topoisomerase inhibitor, ciprofloxacin may exert its adverse effects in human cells by inhibiting ECM (extracellular matrix) protein biosynthesis and stability and inducing MMP (metalloproteinase) activity and even cell death.”

Related: Best Supplements To Kill Candida and Everything Else You Ever Wanted To Know About Fungal Infections

Should I be Worried?

An aortic aneurysm occurs when a tear develops in the inner layers of the aorta and is typically found in men in their 60s or 70s, although they can infrequently develop in pregnant women. You are not likely to get an aortic aneurysm without a previous heart condition or any signs. Symptoms include sudden severe chest, upper back, and abdominal pain; loss of consciousness; shortness of breath; and leg paralysis, among others. High blood pressure and hardened arteries are particularly important risk factors.

Repeat Offender

Fluoroquinolones, the antibiotics at the center of this study, already have FDA warning labels. The earliest version of the label was added in 2008 for an increased risk of tendonitis or tendon rupture. The family of drugs, which consists of levofloxacin, ciprofloxacin, moxifloxacin, ofloxacin, and gemifloxacin, was then associated with a potential increase in nerve damage and a rare neuromuscular disease called myasthenia gravis in 2013. In 2016, the FDA strengthened their warning based on reports of long-term nerve damage and ruptured tendons. Now, these drugs are linked once again to issues with nerve and tendon damage.

Related: How to Detoxify From Antibiotics and Other Chemical Antimicrobials

Science Settled…Wait For It…

We’ve been conditioned to think that antibiotics are safe and nothing to worried about, but antibiotics seriously disrupt our gut environment and have changed the way humans respond to pathogens. It hasn’t been for the better; the changes have left us dependent on stronger and stronger drugs and we are now running out of options. Scientists are beginning to analyze antibiotic use with the greater understanding we’ve acquired through years of trial and error. The lack of serious reflection has been at the expense of our health.

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Antibiotics May Lead to Kidney Stones

The instances of kidney stones have risen dramatically in new demographics like children, women, and African Americans and a newly released study from the Children’s Hospital of Philadelphia has found that taking commonly prescribed antibiotics is a factor in that rise. Researchers examined the health records of 25,981 people 3 to 12 months before their first incidence of kidney stones and a control group consisting of 259,797 people without kidney stones. They discovered that the risk of kidney stones increased after patients were given any of 5 different categories of often used antibiotics; sulfas, cephalosporins, fluoroquinolones, nitrofurantoin/methenamine, and broad-spectrum penicillins. The risk increase was anywhere from 27 percent higher for penicillins to twice that number for sulfonamides. Gregory E. Tasian, MD, MSc, MSCE, a pediatric urologist and epidemiologist at The Children’s Hospital of Philadelphia (CHOP) led the study. Based on his experience,

The emergence of kidney stones in children is particularly worrisome, because there is limited evidence on how to best treat children for this condition…The fact that stones were once rare and are now increasingly common could contribute to the inappropriate use of diagnostic tests such as CT scans for children with kidney stones, since healthcare providers historically have not been accustomed to evaluating and treating children with kidney stones. These trends of increased frequency of kidney stones among adolescents, particularly females, are also concerning when you consider that kidney stones are associated with a higher risk of chronic kidney disease, cardiovascular and bone disease, particularly among young women.”

Related: Natural Remedies for Kidney Stones, Prevention, and What Really Causes Them

Kidney Stones And Other Disease

Long associated with older men, the rising risk of kidney stones among other parts of the population means other, connected health conditions will likely increase as well. Kidney stones have been linked to chronic kidney disease, heart disease, stroke, and bone disease. There has been a correlation between the increase in kidney stones and the increase of some of these conditions, and that’s becoming more difficult to ignore. For example, the lifetime risk for kidney stones for women between 1997 and 2012 rose from 10.5% to 15.2%. Meanwhile, the rate of hospitalization for women aged 35-44 due to acute ischemic strokes rose by 30%.

Related: How to Detoxify From Antibiotics and Other Chemical Antimicrobials

Kidney stones by no means guarantee someone will have a stroke, but both conditions are affecting increasingly younger and more diverse demographics. Kidney stones are likely to reoccur, increasing the risk for other diseases related to kidney stones. What does that look like for a twenty-year-old who has developed kidney stones?

Related: Inexpensive, Easy Detox – The One Gallon Challenge

The Key is Holistic

It’s so easy to look for or focus on a single reason that things have happened. We all want a definitive answer or an easy scapegoat. But the real answers are often messier. Our lives and our health are made up of minute ripples, that we don’t keep track of and forget about until all of a sudden it’s serious. If a recurring issue isn’t addressed at the root cause (likely diet), it will continue to accumulate damage in the body, until the body is no longer able to function properly. Kidney stones are not the only serious health condition becoming more prevalent in younger people. This will be the first generations of Americans with shorter, lower quality lifespans than the previous generation. The system is designed to keep us well enough to function, but that doesn’t always equate with a high quality of life.

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Prescriptions for Dental Procedures – Antibiotic Overuse No One is Paying Attention To

We are watching the end of the antibiotics era, and experts are busy examining all of the usual suspects, but in looking at all of the overprescribing from doctors and veterinarians we’re ignoring another source of antibiotic saturation – the dental industry.

The Quiet Ones

A recent study from the Minnesota Department of Health (MDH) found that 36 percent of dentists report prescribing antibiotics in situations not recommended by the American Dental Association. In 2015, dentists general and specialist combined to issue more than 24.5 million antibiotic prescriptions. Dentists most commonly prescribe penicillin, amoxicillin, and other related antibiotics in that family. Many of these antibiotics are already ineffective against several major bacteria, including E. coli and Streptococcus pneumoniae.

Related: Heal Cavities, Gum Disease, Naturally with Organic Oral Care – Toothpaste recipes included

The consequences of antibiotic overuse are one of the most serious health problems facing the world today, but not everyone recognizes that. Most studies and articles concerning antibiotic resistant-bacteria fails to mention dentists as a factor in that. That is also reflected in the MDH study, where 34 percent of people who recently received antibiotics from a dentist did not have those pharmaceuticals listed on their medical charts. Another worrying trend? Dentists appear to be increasing their rate of prescribing these treatments.

Recommended: How to Kill Fungal Infections

Is Anyone Listening?

As a kid, no one wants to go to the dentist, and it’s clear as an adult that a visit to the dentist for mouth problems is likely to end in a prescription for antibiotics. Dentists are usually ignored or pushed to the side when it comes to discussing health. They are their own insurance category, have an entirely different governing body to report to, and have easily been able to separate the health of the mouth from the health of the rest of the body. We now know that separation does not exist. Holistic dentistry is on the rise but until it’s more accepted, getting a dentist to listen to your concerns about how antibiotics and other procedures could impact your overall health is like…pulling teeth (lolz!).

Related: How to Detoxify From Antibiotics and Other Chemical Antimicrobials

So what do you do?

  • There are two things that all dentists recommend that are essential: brush and floss. Stop cheating. Routine is your friend.
  • Look up oil pulling and start doing it. At first, this is easier said than done. The oil feels slimy, and the average person’s jaw is simply not ready for twenty minutes of sustained swishing. Work up to it.
  • Getting in front of an infection is super important. If you’re feeling any kind of pain, assume it’s an infection and chew on raw garlic for as long as you can before spitting it out. Even if you don’t technically have an infection yet, a round or two of that will knock it right out.
  • Sugar does not cause cavities. But sugar feeds the less desirable bacteria in the mouth and gut, allowing infections to more easily take root. Replacing sugar with fresh raw produce feeds the beneficial bacteria and maintain a healthy homeostasis. Diet is the key to holistic health, and we often forget to include the mouth in that.

Health Comes First

Antibiotic-resistant bacteria will kill 10 million people a year by 2050 if things stay the same. Many medical journals, doctors, and researchers are sounding the alarm. Though dentists don’t seem to be as concerned, they are the issuers of 24.5 million antibiotic prescriptions a year, and they need to be part of the conversation.

Related: How to Detoxify From Chemotherapy and Repair the Body

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WHO Says the World Will Run Out of Antibiotics Able to Treat Bacteria Superbugs

Antibiotic-resistant infections are on the rise. The World Health Organization released a list of the 12 different bacteria strains that could pose the highest level of risk to human health. The list, divided into three sections based on how critical the threat is, represents health problems the WHO feels we should be solving. Conventional medicine is not likely to have those answers. WHO, publishers of the “priority pathogens” list, reports that there are not enough new antibiotics in development to adequately combat these microbes, and the rate that bacteria develops resistance at will outpace new drug development soon.

Antibiotic-Resistant Bacteria Are and Will Be a Big Problem

Antibiotic-resistant bacteria is scary. The leading cause of death worldwide, ischaemic heart disease, claims 8 million people. If we continue at the current rate of prescribing antibiotics for people, animals, and livestock, 10 million people will die of antibiotic-resistant infections by the year 2050. WHO’s top three “priority pathogens” are Acinetobacter baumannii, pseudomonas aeruginosa, and enterobacteriaceae (E.coli). All three of these infections have already demonstrated significant resistance to antibiotic treatments.

Related: After Taking Antibiotics, This Is What You Need To Do To Restore Healthy Intestinal Flora

What’s Going On With the New Drugs?

So let’s talk about the new antibiotics. Of the 51 antibiotics and biologicals currently in development to treat these “priority pathogens,” the WHO only classifies 8 of them as innovative. The other 25 are modifications of existing treatments and will only function as stop-gap measures.

Why aren’t more antibiotics in the pipeline when numerous health organizations have explicitly stated the worldwide need for them? There isn’t a good answer to that questions, although profit margins are the most likely answer. Antibiotics aren’t meant for long-term use, and the decade long research and development period affects pharmaceutical companies’ return on investment. Drug companies are also reluctant to manufacture orally administered antibiotics, their most accessible form.

Fourteen percent of the drugs currently in development make it to market, and medical professionals argue that needs to change. But fewer drug hurdles are not the answer. More antibiotics aren’t the answer either.

Related: How C. Diff Infections Decrease with Fewer Antibiotics

Why Antibiotics Don’t Work Even When They Work

Doctors did not regularly prescribe colistin. Although powerful, it’s an older drug and causes severe kidney damage. That changed when resistance to modern, more highly-regarded antibiotics became more commonplace, and colistin became the antibiotics of last resort. Now that has changed. Chinese pig farmers used colistin when doctors stopped prescribing it, and the first colistin resistant gene was recorded in November 2015. The gene has spread worldwide, and scientists and healthcare professionals don’t have an answer yet.

Related: How to Detoxify From Antibiotics and Other Chemical Antimicrobials

Should antibiotics be part of the answer though? Drug-resistant strains of bacteria generally occur in people who are already sick and those with weak immune systems. Sick people are given antibiotics. Antibiotics eliminate beneficial bacteria, and damage the immune system. Antibiotic-resistant bacteria has developed in response to an overuse of antibiotics. It’s naive to imagine a world where we go cold-turkey on antibiotics, but every antibiotic usage is giving like the strongest bacteria another opportunity to figure out to survive treatment.

A Few Tips to Not Need Antibiotics

The first step to getting rid of antibiotic use is build up your immune system naturally. If you don’t get sick, there is no need for antibiotics. To do that, you need an immune system ready to take on anything. It’s easier to make and stick to a series of small changes, and there are plenty ways you can start building your immune system today with items found at the average grocery store.

Certain herbs, especially garlic, are your new best friends.

Oregano, calendula, echinacea, and goldenseal are some relatively accessible herbs that boost the immune system. Even easier to find? Garlic. Raw garlic can be added to salads, in snacks, and on dinners. Infections want an easy target, and the allicin found in garlic is a powerful deterrent to those harmful pathogens. If you have a mouth infection, chewing on raw garlic can be beneficial.

Tighten up your diet, and learn to love salads.

Eat as many whole, homemade foods as possible. Your meal prep should become a vegetable version of the will it float game from the Letterman version of the Late Show – Will. It. Salad! The answer is usually yes. The more fresh vegetables, the better. My favorite way to break up that monotony is with homemade hummus, quinoa, fresh tomatoes, and lemon juice. Refined sugar in its many forms damages the body, feeding fungus, bacteria, viruses, and other parasites while lowering the body’s immune system.

Prioritize your sleep.

Sleep deprivation causes an estimated 100,000 car accidents every year. Businesses in U.S. lose 411 million dollars a year due to a lack of sleep. It also makes you more susceptible to pathogens and infection. Lack of sleep suppresses the immune system. According to Diwakar Balachandran, director of the Sleep Center at the University of Texas M.D. Anderson Cancer Center, “A lot of studies show our T-cells go down if we are sleep deprived…and inflammatory cytokines go up.” The ultimate in sleeping resets is electronic-free camping for a few days, but most people aren’t able to regularly do that. Popular herbal treatments include B vitamins, healthy fats like vitamin D, tryptophan, valerian root, and chamomile root.

Related: Some Antibiotics May Blind, Cripple, or Kill You

The Creation of Superbugs and Superweeds – Another Strike Against GMOs

Supporters of genetically modified organisms (GMOs) say that they lower the use of pesticides and benefit the environment. However, the record demonstrates that there are growing negative environmental impacts from GMOs. One major problem caused by the widespread use of GMOs, and the herbicides and pesticides they were developed to withstand, is the emergence of superweeds and superbugs – plants and insects now resistant to these chemicals.” – GMO Inside.org

Personal Preparedness

The rise of antibiotic-resistant bacteria and climate change are linked by more than factory farming. We need to rethink the way we prepare for both of these things. The WHO is looking for antibiotics, but antibiotics have played a critical part in developing these bugs. Our food and environment dictate our health, and we have more control over that than modern medicine would have you believe.

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Antibiotics and Rectal Cancer – There’s a Connection You Should Know About

Colorectal cancer rates are more than doubling in a particularly disturbing way. A new study from the American Cancer Society (ACS) analyzing cancer occurrences discovered that diagnoses of colorectal cancer have increased every generation since 1950. Scientists are unsure of the cause. But luckily for them, another new study has discovered that prolonged use of antibiotics can be linked to the increased the likelihood of bowel polyps, a precursor to rectal and colon cancers. Together, both studies make a compelling argument for the long-term consequences of our current antibiotic use and food system.

They Get Younger Every Year

Cancer is now a fact of life. The likelihood that you or someone you know well has been diagnosed with cancer is already high, and the number of cases diagnosed is predicted to rise to more than 21 million people in 2030. Colon and Rectal cancers are some of the most common cancers, 90% of colon and rectal cancer cases occur in people over the age of 50. According to Rebecca Siegel, the lead author of a new study from the American Cancer Society, “People born in 1990…have double the risk of colon cancer and quadruple the risk of rectal cancer” compared to the risk someone born in 1950 faced at a comparable age.

The American Cancer Society expects to see 13,500 new cases of colon and rectal cancer in people under 50 in 2017. At this point, someone under 50 is more likely to be diagnosed with colon or rectal cancer than the likelihood of anyone of any age is to receive a diagnosis for a less common cancer like Hodgkin’s Lymphoma. The conventional Western diet induces and intensifies inflammation in colonic mucosa within two weeks of being on a conventional Western diet, and that inflammation is one of the precursors of cancer. While the study from the ACS does address diet briefly, it also gives the impression that cancer is something that is just going to happen. But this is where that other study comes in.

Polyp, Polyp, Polyp

For every disease or condition that develops in the body, there are warning signs as it develops. For rectal cancer, one of those signs is small growths on the lining of the bowel known as polyps. Not all bowel polyps are cancerous, but they can develop into cancer later if the issue isn’t addressed.  But how do the polyps get there? A study looking at data from a long-term nurses’ health study found that nurses from ages 20 to 39 who had taken antibiotics for at least two months were later in life more likely to be diagnosed with adenomas (a specific type of bowel polyp) than nurses who had not taken antibiotics for a sustained period of time.

Polyps are not the same thing as rectal or colon cancer. It’s likely that if you have polyps that you will never notice their presence. But imagine you took antibiotics for a prolonged period from the ages of one to twenty. Then you took antibiotics for a prolonged period of time from ages twenty to thirty. You also have to contend with the possibility that you are ingesting a steady stream of antibiotics if you consume conventional meat regularly. Each time you come into contact with antibiotics for an extended period of time, the likelihood of developing adenomas increases.

The Steps Are There

These two studies make a compelling argument for the management of cancer risk through lifestyle. Choose to limit antibiotics in the food you eat and medicinal purposes, either through vegetarianism, veganism, natural remedies, or informed consumption. Replace typical health pitfalls like a sedentary lifestyle and a conventional western diet with regular movement and load up on fresh, raw organic produce. With each positive choice, the likelihood of rectal cancer (or any cancer at all) decreases. There is no cancer treatment available that can replicate the benefits of taking care of yourself first.

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